Activation of Nuclear Factor-κB in Unstable Angina
نویسندگان
چکیده
منابع مشابه
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory d...
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Apoptosis is a mode of cell death that plays an important role in both pathological and physiological processes. Research during the last decade has delineated the entire machinery needed for cell death, and its constituents were found to pre-exist in cells. The apoptotic cascade is triggered when cells are exposed to an apoptotic stimulus. It has been known for several years that inhibitors of...
متن کاملNMR-based plasma metabolic profiling in patients with unstable angina
Objective(s): Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In this study, we proceeded to investigate metabolite profiling in UA patients compared with controls to determine potential candidate...
متن کاملhyperglycemia-induced nuclear factor-κB activation and systemic inflammation
3 4 Authors: Steven K. Malin1,2, John P. Kirwan1,2, Chang Ling Sia3, and Frank González3 5 6 7 1Dept. of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 8 2Dept. of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH; 9 3Dept. of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN. 10 11 12 13 14 Funding: Nationa...
متن کاملActivation of cardiac renin-angiotensin system in unstable angina.
OBJECTIVES The aim of this study was to investigate the activity of the cardiac renin-angiotensin system (RAS) in unstable angina (UA). BACKGROUND Angiotensin (Ang) II locally produced by continuously operating cardiac RAS may affect the pathophysiology of UA. METHODS In 35 patients with UA, 32 with stable effort angina (SA) and 21 with atypical chest pain (controls), cardiac RAS was invest...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.100.13.1462a